Tuba Angay-Crowder, PhD, Postdoctoral Researcher in the Bagwell College of Education
Aug. 2021 - Present
Research Interests/Projects
Interest: Transnational and multimodal practices of multilinguals.
Interest: Language teacher identities.
Interest: Culturally sustaining pedagogies.
Interest: Critical language awareness.
Project: Currently, we examine how language teachers implement translanguaging as pedagogy
and practices in a dual language immersion program in an elementary school in Georgia.
The ultimate goal of the project is to promote plurilingual approaches in education
and integrating translanguaging practices into content areas and providing professional
development opportunities for the teachers.
John Barrows, PhD, Postdoctoral Researcher in the College of Science and Mathematics
Aug. 2021 - Present
Research Interests/Projects
Interest: Regulation of gene expression in prokaryotes.
Interest: Interactions between DNA and transcription regulatory proteins.
Project: Iron homeostasis in extremophiles. In this work, our laboratory seeks to discovery
the biological function of three ferric uptake regulator homologs in the extreme thermophile,
Thermus thermophilus. These proteins regulate gene expression when complexed with heavy metal co-factors.
Therefore, they likely play a significant role in the recognition and response to
environmental metals. We have established a novel, combinatorial approach to identify
the preferred DNA-binding sequence of each of these proteins. From these results we
will identify their transcription regulatory networks and shed novel insight into
how this organism senses and responds to metals in their environment.
Tyler Collette, PhD, Postdoctoral Researcher in the Radow College of Humanities and
Social Sciences
Oct. 2020 - Present
Research Interests/Projects
Interest: Culturally competent interventions for vulnerable populations.
Project: Healthy Together: A culturally competent self-management program for low-income African-American
men.
Interest: Identifying the mechanisms for resilience after traumatic experiences.
Project: Mechanisms of Trauma and Resilience: Evaluating cultural worldview as an anxiety
buffer between adverse life events and post traumatic growth.
Kyle Gabriel, PhD, Postdoctoral Researcher in the College of Science and Mathematics
May 2017 - Present
Research Interests/Projects
Interests: Applied sciences.
Projects: Serve as PI and Co-PI on several grants investigating fungal pathogen and disease
mitigation (bat white-nose syndrome) and the development of renewable growth substrates
and semi-automated cultivation methods for culinary mushroom production, among other
projects. You can learn more about our lab at https://bioinnovation.kennesaw.edu
Gaurav Kumar, Postdoctoral Researcher in the College of Science and Mathematics
June 2021 - Present
Research Interests/Projects
Interest: Identification proteins for transferrin endocytosis in the African trypanosome.
Project: The protozaon Trypanosoma brucei causes human African trypanosomiasis (HAT), a neglected tropical disease. Endocytosis
of the host protein, transferrin (Tf) is essential for trypanosome survival in a vertebrate
host. However, the pathway for endocytosis of Tf is not completely characterized in
the trypanosome. Most T. brucei genes lack homologs in model eukaryotes, making it difficult to completely delineate
biological pathways using protein sequence alignments. We use a “discovery chemical
biology” strategy to identify Transferrin (Tf) endocytosis pathway proteins in the
African trypanosome. A small-molecule pyrrolopyrimidine AEE788, a kinase inhibitor,
was used as a chemical probe of Tf endocytosis. Phosphoproteome analysis of AEE788-
treated cells led to identification of a pseudokinase, Tb427tmp.160.4770 (TbNRP1)
as a possible pathway protein for Tf endocytosis. We then employed a genetic approach
(knock down of TbNRP1 by RNA interference) to validate TbNRP1’s role in endocytosis
of Tf. Phosphoproteome data from knockdown of TbNRP1 and from “discovery chemical
biology” strategy with AEE788 led to the identification of six new proteins that are
under investigation as mediators Tf endocytosis in T. brucei.
Matthew Lyons, PhD, Postdoctoral Researcher in the Wellstar College of Health and
Human Services
Aug. 2021 - Present
Research Interests/Projects
Interest: Investigating the full causal pathway from the social and physical environment, through
the biological mediators of disease, to adverse health outcomes.
Project: Quantitative investigation of differences between youth in the US and Uganda with
regard to attitudes and experiences with both alcohol and violence (N = 600).
Interest: Development, implementation, evaluation, and dissemination of evidence-based programs
to intervene along the causal pathway from environment to disease with the aim of
preventing adverse health outcomes.
Project: Longitudinal analysis of trajectories and predictors of SafeCare implementation fidelity
in a sample containing 15,000 observations nested within 850 service providers.
Jason A. Shar, PhD, Postdoctoral Researcher in the Southern Polytechnic College of
Engineering and Engineering Technology
Aug. 2021 - Present
Research Interests/Projects
Interests: Bridging the gap between mechanics and biology by developing a comprehensive understanding
of the potential causalities between abnormal blood flow and disease pathways.
Project: Investigating the cardiovascular risks posed by obese pregnancy on acquired pathologies
such as acute aortic dissection.
Project: Assessing the mechanobiological impact of microgravity and radiation from long-duration
spaceflight on the carotid bifurcation.
Project: Elucidating the role of blood flow and associated wall shear stress abnormalities
resulting from hypertension on aortic valve calcification.
Amrita Sharma, PhD, Postdoctoral Researcher in the College of Science and Mathematics
Aug. 2021 - Present
Research Interests/Projects
Interest: Drug Development for Diseases Caused by the African Trypanosome; Molecular Mechanisms
of Drug Action
Project: Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei rhodesiense and T. b. gambiense which establish acute and chronic infection, respectively. This disease is a threat
to ~70 million people. Due to antigenic variation, vaccines cannot be produced against
T. brucei. Current chemotherapy has some undesirable properties, necessitating the development
of safer orally bioavailable drug leads with different mode(s) of action than the
existing drugs. The approved drug lapatinib and a hit curaxin CBL0137 were explored
as a starting point for the synthesis of new chemical entities in a medicinal chemistry
campaign. New hits with improved physicochemical properties and potency against T. brucei have been obtained. Our studies aim to advance development of novel lead drugs, explore
their molecular mode(s) of action, and identify their targets in T. brucei.